Postdoctoral Fellow Genome Editing (14 Rp11236)

Job Purpose

To establish a robust system for CRISPR/Cas9-mediated genome engineering in rice that allows for the generation of stable targeted mutations, insertions and allele replacements. To facilitate the the adoption of CRISPR-based genome editing approaches in IRRI research and development (R&D) with aim improve speed and precision of trait development pipelines. 

The position is based in IRRI Headquarters Los Baños, Laguna, Philippines.  Globally Recruited Staff benefits can be found here. 

Roles and Responsibilities

1. Generate and test a variety of components used in genome editing approaches for applied rice R&D
- Generate and test the utility of multiplexed sgRNA delivery systems
- Generate and test the utility of replicon-based nuclease and template delivery sytems
- Generate and test spatio-temporal regulation of Cas9 delivery systems
- Generate and test the utility of split Cas9 systems
- Investigate and test new promising approaches for applied CRISPR-based genome editing as they appear in the literature

2. Demonstrate utility of multi-component CRISPR/Cas9 systems in applied R&D
- Improve a trait via targeted, CRISPR-mediated mutigenesis of a known trait-conferring allele (SDN1-type)
- Improve a trait via CRISPR-mediated allele replacement of a known trait-conferring allele (SDN2-type)
- Improve a trait via targeted, CRISPR-mediated gene-insertion of a known trait-conferring gene (SDN3-type)

3. Collaborate internally and externally and communicate to peers
- Collaborate with IRRI molecular biologists and trait developers to optimize the system and facilitate its adoption among stakeholder R&D groups
- Establish and maintain an international collaboration with a highly reputed scientists in the field
- Write and publish articles in peer-reviewed journals.
- Present findings at international conferences/workshops and symposia.
- Demonstrate exceptional people management skills

4. Supervise staff on experimental design and data interpretation
- Carry out performance appraisals
- Contribute to the professional development of staff 
- Contribute internal capacity building

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